01/By surface
each with its own count, at equal weight
Hard
2-0
R. leads 2-0 in 2 meetings on hard
Clay
3-0
R. leads 3-0 in 3 meetings on clay
Grass
Never on grass
no meeting on this surface
02/Every meeting
5 rows, newest first
| Date | Tournament | Surface | Round | Winner | Score, winner first | Ranks, R. first |
|---|---|---|---|---|---|---|
| May 11, 2022 | Internazionali BNL d'ItaliaMasters 1000 | clay | 2nd round | Nadal R. | 6-3, 6-1 | 4 v 27 |
| Oct 6, 2017 | China OpenATP500 | hard | quarterfinal | Nadal R. | 6-4, 7-6 | 1 v 17 |
| May 14, 2015 | Internazionali BNL d'ItaliaMasters 1000 | clay | 3rd round | Nadal R. | 6-4, 6-4 | 7 v 17 |
| Apr 16, 2015 | Monte Carlo MastersMasters 1000 | clay | 3rd round | Nadal R. | 7-6, 4-6, 6-3 | 5 v 19 |
| Aug 18, 2013 | Western & Southern Financial Group MastersMasters 1000 | hard | final | Nadal R. | 7-6, 7-6 | 3 v 22 |
A record, never a share of meetings. Main-draw singles since 2013; a meeting ended by retirement is counted with the sets that were played and marked; a walkover is listed and counted in neither column. Nadal R. and Isner J. each carry the table against every opponent faced.